First off, ‘Guadalupe In The Guest Room’ is not about the Virgen de Guadalupe, the Virgin Mary, it is about a woman from Mexico named Guadalupe, played by Megally Luna, who has come to the U.S. to care for her ailing daughter. The daughter, Claudia, has passed away and she is now a guest in the home of her daughter’s husband. Guadalupe doesn’t speak English and Steve doesn’t speak Spanish.